Drug interactions
Methotrexate + Tetanus toxoid adsorbed or fluid
Severity: Minor
Methotrexate and Tetanus toxoid adsorbed or fluid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate can weaken the antibody response to tetanus toxoid. Protective titers may be lower than in untreated people.
What this interaction means in plain words
Methotrexate and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Methotrexate suppresses lymphocyte proliferation needed for vaccine response.
What to do
Vaccinate as scheduled, since the toxoid is non-live and remains recommended. Give a booster promptly after a tetanus-prone wound.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Tetanus toxoid adsorbed or fluid?
MediHelp rates the interaction as minor. Methotrexate and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methotrexate can weaken the antibody response to tetanus toxoid. Protective titers may be lower than in untreated people.
How serious is the interaction between Methotrexate and Tetanus toxoid adsorbed or fluid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as scheduled, since the toxoid is non-live and remains recommended. Give a booster promptly after a tetanus-prone wound.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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