Drug interactions
Methotrexate + Typhoid polysaccharide vaccine
Severity: Moderate
Methotrexate and Typhoid polysaccharide vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate suppresses immune function and may blunt the antibody response to inactivated vaccines such as the Vi polysaccharide typhoid vaccine. Patients may therefore be incompletely protected after vaccination.
What this interaction means in plain words
Methotrexate and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate-induced immunosuppression and inhibition of lymphocyte proliferation reduce vaccine immunogenicity.
What to do
Where possible give the vaccine at least 2 weeks before starting methotrexate or during a planned treatment break. If vaccination occurs during therapy, still vaccinate if travel risk is real and do not rely on full protection, so reinforce food and water precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as moderate. Methotrexate and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate suppresses immune function and may blunt the antibody response to inactivated vaccines such as the Vi polysaccharide typhoid vaccine. Patients may therefore be incompletely protected after vaccination.
How serious is the interaction between Methotrexate and Typhoid polysaccharide vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible give the vaccine at least 2 weeks before starting methotrexate or during a planned treatment break. If vaccination occurs during therapy, still vaccinate if travel risk is real and do not rely on full protection, so reinforce food and water precautions.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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