Drug interactions
Methotrexate + Valoctocogene roxaparvovec
Severity: Moderate
Methotrexate and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec commonly causes transaminase elevations, and methotrexate is itself hepatotoxic. Combining them may increase the risk of liver injury and could compromise gene transfer expression.
What this interaction means in plain words
Methotrexate and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxicity from two agents that can each injure the liver.
What to do
Check liver enzymes regularly after gene therapy as per labeling and consider an alternative to methotrexate when feasible. If ALT rises, review all hepatotoxic drugs with the hepatology team.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Methotrexate with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Methotrexate and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec commonly causes transaminase elevations, and methotrexate is itself hepatotoxic. Combining them may increase the risk of liver injury and could compromise gene transfer expression.
How serious is the interaction between Methotrexate and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes regularly after gene therapy as per labeling and consider an alternative to methotrexate when feasible. If ALT rises, review all hepatotoxic drugs with the hepatology team.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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