Drug interactions
Methotrexate + Zoster vaccine recombinant
Severity: Minor
Methotrexate and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate can reduce the antibody and cellular response to vaccines. The recombinant zoster vaccine is non-live and safe in immunosuppressed patients, but protection may be lower.
What this interaction means in plain words
Methotrexate and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunosuppression by methotrexate lowers the vaccine-induced immune response.
What to do
Vaccinate according to guidelines without stopping methotrexate, or time vaccination with a treatment break if the disease is stable. Complete the two-dose schedule.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Methotrexate and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methotrexate can reduce the antibody and cellular response to vaccines. The recombinant zoster vaccine is non-live and safe in immunosuppressed patients, but protection may be lower.
How serious is the interaction between Methotrexate and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to guidelines without stopping methotrexate, or time vaccination with a treatment break if the disease is stable. Complete the two-dose schedule.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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