Drug interactions
Methoxyflurane + Tetracycline
Severity: Contraindicated
Methoxyflurane and Tetracycline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane releases fluoride that can injure the kidney, and tetracyclines can worsen renal function through their anti-anabolic effect. Combined use has been associated with fatal renal toxicity. Labeling advises against the combination.
What this interaction means in plain words
Methoxyflurane and Tetracycline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive nephrotoxicity from methoxyflurane fluoride metabolites and tetracycline-related renal impairment.
What to do
Avoid concurrent use and choose a non-tetracycline antibiotic if methoxyflurane is needed. Monitor renal function if exposure has occurred.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
- Tetracycline + Typhoid vaccine live Major
Frequently asked questions
Can I take Methoxyflurane with Tetracycline?
MediHelp rates the interaction as contraindicated. Methoxyflurane and Tetracycline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methoxyflurane releases fluoride that can injure the kidney, and tetracyclines can worsen renal function through their anti-anabolic effect. Combined use has been associated with fatal renal toxicity. Labeling advises against the combination.
How serious is the interaction between Methoxyflurane and Tetracycline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-tetracycline antibiotic if methoxyflurane is needed. Monitor renal function if exposure has occurred.
What other medicines interact with Tetracycline?
MediHelp also lists interactions of Tetracycline with, for example, Acitretin, Isotretinoin, Palovarotene. The full list is on the Tetracycline page.
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