Drug interactions
Methyclothiazide + Terbutaline
Severity: Moderate
Methyclothiazide and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both terbutaline and thiazide diuretics can lower serum potassium. Combined use may cause clinically significant hypokalemia, which increases the risk of arrhythmias and muscle weakness, especially with high-dose or repeated terbutaline.
What this interaction means in plain words
Methyclothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2-mediated cellular potassium uptake plus thiazide-induced renal potassium loss.
What to do
Monitor serum potassium and magnesium, particularly at the start of therapy or when terbutaline doses are increased. Supplement potassium or add a potassium-sparing agent if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Frequently asked questions
Can I take Methyclothiazide with Terbutaline?
MediHelp rates the interaction as moderate. Methyclothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both terbutaline and thiazide diuretics can lower serum potassium. Combined use may cause clinically significant hypokalemia, which increases the risk of arrhythmias and muscle weakness, especially with high-dose or repeated terbutaline.
How serious is the interaction between Methyclothiazide and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly at the start of therapy or when terbutaline doses are increased. Supplement potassium or add a potassium-sparing agent if hypokalemia develops.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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