Drug interactions
Methylenedioxymethamphetamine + Terbutaline
Severity: Moderate
Methylenedioxymethamphetamine and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA releases monoamines and produces marked sympathomimetic effects such as tachycardia, hypertension, hyperthermia and arrhythmia. Terbutaline adds direct beta-adrenergic stimulation, which may increase cardiovascular strain.
What this interaction means in plain words
Methylenedioxymethamphetamine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects from indirect monoamine release (MDMA) and direct beta-2 agonism (terbutaline).
What to do
Advise patients against recreational MDMA use while on terbutaline. If exposure occurs, monitor heart rate, blood pressure, temperature and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Frequently asked questions
Can I take Methylenedioxymethamphetamine with Terbutaline?
MediHelp rates the interaction as moderate. Methylenedioxymethamphetamine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA releases monoamines and produces marked sympathomimetic effects such as tachycardia, hypertension, hyperthermia and arrhythmia. Terbutaline adds direct beta-adrenergic stimulation, which may increase cardiovascular strain.
How serious is the interaction between Methylenedioxymethamphetamine and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients against recreational MDMA use while on terbutaline. If exposure occurs, monitor heart rate, blood pressure, temperature and ECG.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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