Drug interactions
Methylergonovine + Pimozide
Severity: Minor
Methylergonovine and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is metabolized by CYP3A4, and pimozide is only a weak inhibitor, so a pharmacokinetic effect is unlikely to be substantial. Any serotonergic and dopaminergic interplay is largely theoretical for short-term obstetric use.
What this interaction means in plain words
Methylergonovine and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive serotonergic and dopaminergic effects; no well-established mechanism.
What to do
No routine adjustment is needed for short-term methylergonovine use. Monitor for serotonin toxicity or hyperthermia if used for longer.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Methylergonovine with Pimozide?
MediHelp rates the interaction as minor. Methylergonovine and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylergonovine is metabolized by CYP3A4, and pimozide is only a weak inhibitor, so a pharmacokinetic effect is unlikely to be substantial. Any serotonergic and dopaminergic interplay is largely theoretical for short-term obstetric use.
How serious is the interaction between Methylergonovine and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed for short-term methylergonovine use. Monitor for serotonin toxicity or hyperthermia if used for longer.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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