Drug interactions
Methylergonovine + Xylometazoline
Severity: Moderate
Methylergonovine and Xylometazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is a strong vasoconstrictor and xylometazoline is a nasal alpha agonist with low but real systemic absorption. Additive vasoconstriction and hypertension are possible, particularly postpartum when blood pressure may already be raised.
What this interaction means in plain words
Methylergonovine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasoconstriction from alpha-adrenergic agonism and ergot-induced smooth muscle contraction.
What to do
Avoid xylometazoline during methylergonovine treatment where possible. Monitor blood pressure if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Frequently asked questions
Can I take Methylergonovine with Xylometazoline?
MediHelp rates the interaction as moderate. Methylergonovine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylergonovine is a strong vasoconstrictor and xylometazoline is a nasal alpha agonist with low but real systemic absorption. Additive vasoconstriction and hypertension are possible, particularly postpartum when blood pressure may already be raised.
How serious is the interaction between Methylergonovine and Xylometazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid xylometazoline during methylergonovine treatment where possible. Monitor blood pressure if used.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
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