Drug interactions
Metoclopramide intranasal + Octreotide
Severity: Minor
Metoclopramide intranasal and Octreotide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide slows gastrointestinal motility, which may change the absorption of metoclopramide. Reduced absorption could lessen the prokinetic or antiemetic benefit of the nasal product.
What this interaction means in plain words
Metoclopramide intranasal and Octreotide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Octreotide-induced reduction in GI motility may alter metoclopramide absorption; the effect is largely theoretical.
What to do
Monitor for reduced symptom control of gastroparesis. Consider a different route or dose adjustment if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Octreotide
Frequently asked questions
Can I take Metoclopramide intranasal with Octreotide?
MediHelp rates the interaction as minor. Metoclopramide intranasal and Octreotide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Octreotide slows gastrointestinal motility, which may change the absorption of metoclopramide. Reduced absorption could lessen the prokinetic or antiemetic benefit of the nasal product.
How serious is the interaction between Metoclopramide intranasal and Octreotide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control of gastroparesis. Consider a different route or dose adjustment if response is inadequate.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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