Drug interactions
Metoclopramide intranasal + Remifentanil
Severity: Moderate
Metoclopramide intranasal and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause sedation and extrapyramidal effects, and opioids antagonize its prokinetic action. Both can add to CNS depression.
What this interaction means in plain words
Metoclopramide intranasal and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and opposing effects on gastrointestinal motility (opioid-mediated dopaminergic and cholinergic antagonism of prokinetic action).
What to do
Monitor sedation and gastrointestinal response, and consider an alternative antiemetic if prokinetic effect is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Frequently asked questions
Can I take Metoclopramide intranasal with Remifentanil?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause sedation and extrapyramidal effects, and opioids antagonize its prokinetic action. Both can add to CNS depression.
How serious is the interaction between Metoclopramide intranasal and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and gastrointestinal response, and consider an alternative antiemetic if prokinetic effect is needed.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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