Drug interactions
Metoclopramide intranasal + Theophylline
Severity: Moderate
Metoclopramide intranasal and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may raise the rate of theophylline absorption and has been linked to higher theophylline concentrations. Both drugs can also lower the seizure threshold or cause central effects. The clinical effect is usually modest.
What this interaction means in plain words
Metoclopramide intranasal and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased gastric emptying may accelerate theophylline absorption; any other mechanism is not clearly established.
What to do
Monitor theophylline levels and for signs of toxicity such as tremor, tachycardia or nausea; adjust the theophylline dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Metoclopramide intranasal with Theophylline?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide may raise the rate of theophylline absorption and has been linked to higher theophylline concentrations. Both drugs can also lower the seizure threshold or cause central effects. The clinical effect is usually modest.
How serious is the interaction between Metoclopramide intranasal and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline levels and for signs of toxicity such as tremor, tachycardia or nausea; adjust the theophylline dose if needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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