Drug interactions
Metoclopramide intranasal + Zaleplon
Severity: Moderate
Metoclopramide intranasal and Zaleplon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness and dizziness, so combined use with zaleplon may increase sedation and impaired alertness.
What this interaction means in plain words
Metoclopramide intranasal and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; no specific pharmacokinetic mechanism established.
What to do
Monitor for excessive sedation and advise caution with driving; use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Metoclopramide intranasal with Zaleplon?
MediHelp rates the interaction as moderate. Metoclopramide intranasal and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause drowsiness and dizziness, so combined use with zaleplon may increase sedation and impaired alertness.
How serious is the interaction between Metoclopramide intranasal and Zaleplon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise caution with driving; use the lowest effective doses.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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