Drug interactions
Metronidazole + Mobocertinib
Severity: Major
Metronidazole and Mobocertinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib is metabolized by CYP3A4 and causes dose-related QTc prolongation. Both drugs have been associated with QT effects, and any rise in mobocertinib exposure could add to this risk.
What this interaction means in plain words
Metronidazole and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Possible weak CYP3A4 inhibition raising mobocertinib levels, combined with additive QT-prolonging effects.
What to do
Avoid the combination if an alternative antimicrobial exists. If it is needed, monitor ECG and electrolytes and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Metronidazole with Mobocertinib?
MediHelp rates the interaction as major. Metronidazole and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib is metabolized by CYP3A4 and causes dose-related QTc prolongation. Both drugs have been associated with QT effects, and any rise in mobocertinib exposure could add to this risk.
How serious is the interaction between Metronidazole and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antimicrobial exists. If it is needed, monitor ECG and electrolytes and correct potassium and magnesium.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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