Drug interactions
Metronidazole + Mycophenolic acid
Severity: Moderate
Metronidazole and Mycophenolic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole alters gut flora, and combined with norfloxacin has been associated with lower mycophenolic acid exposure and possible reduced immunosuppression.
What this interaction means in plain words
Metronidazole and Mycophenolic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Mycophenolic acid belongs to Miscellaneous.
Why it happens
Reduced gut bacterial deconjugation of MPA glucuronide decreases enterohepatic recycling.
What to do
Monitor for signs of rejection or reduced efficacy during and after the antibiotic course. Consider MPA exposure monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metronidazole and Mycophenolic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mycophenolic acid
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Metronidazole with Mycophenolic acid?
MediHelp rates the interaction as moderate. Metronidazole and Mycophenolic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metronidazole alters gut flora, and combined with norfloxacin has been associated with lower mycophenolic acid exposure and possible reduced immunosuppression.
How serious is the interaction between Metronidazole and Mycophenolic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of rejection or reduced efficacy during and after the antibiotic course. Consider MPA exposure monitoring.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Cholestyramine. The full list is on the Mycophenolic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
