Drug interactions
Metronidazole + Nirogacestat
Severity: Moderate
Metronidazole and Nirogacestat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirogacestat is cleared mainly by CYP3A4, and stronger inhibitors increase exposure and toxicity such as diarrhea, hepatotoxicity and ovarian toxicity. Metronidazole is a weak inhibitor, so any effect is probably limited.
What this interaction means in plain words
Metronidazole and Nirogacestat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Nirogacestat belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing nirogacestat clearance.
What to do
Monitor for diarrhea and liver enzyme changes while on both drugs. Consider a non-interacting antimicrobial where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Nirogacestat
Frequently asked questions
Can I take Metronidazole with Nirogacestat?
MediHelp rates the interaction as moderate. Metronidazole and Nirogacestat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nirogacestat is cleared mainly by CYP3A4, and stronger inhibitors increase exposure and toxicity such as diarrhea, hepatotoxicity and ovarian toxicity. Metronidazole is a weak inhibitor, so any effect is probably limited.
How serious is the interaction between Metronidazole and Nirogacestat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and liver enzyme changes while on both drugs. Consider a non-interacting antimicrobial where suitable.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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