Drug interactions
Metronidazole + Olaparib
Severity: Moderate
Metronidazole and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib is metabolized mainly by CYP3A, and inhibitors can raise its exposure and increase hematologic toxicity. Metronidazole is a weak inhibitor, so a significant effect is unlikely but cannot be excluded.
What this interaction means in plain words
Metronidazole and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Olaparib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole reducing olaparib metabolism.
What to do
Monitor complete blood counts for anemia, neutropenia and thrombocytopenia. Reduce the olaparib dose only if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Metronidazole with Olaparib?
MediHelp rates the interaction as moderate. Metronidazole and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib is metabolized mainly by CYP3A, and inhibitors can raise its exposure and increase hematologic toxicity. Metronidazole is a weak inhibitor, so a significant effect is unlikely but cannot be excluded.
How serious is the interaction between Metronidazole and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts for anemia, neutropenia and thrombocytopenia. Reduce the olaparib dose only if toxicity develops.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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