Drug interactions
Metronidazole + Pyridoxine
Severity: Minor
Metronidazole and Pyridoxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral metronidazole may theoretically reduce intestinal bacterial vitamin production, but dietary pyridoxine is the main source and no clinically important depletion is established. Notably, both metronidazole and excess pyridoxine can cause peripheral neuropathy.
What this interaction means in plain words
Metronidazole and Pyridoxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical alteration of intestinal flora that synthesize vitamins.
What to do
No action is needed at usual doses; avoid high-dose pyridoxine during prolonged metronidazole courses and watch for neuropathy symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Metronidazole with Pyridoxine?
MediHelp rates the interaction as minor. Metronidazole and Pyridoxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral metronidazole may theoretically reduce intestinal bacterial vitamin production, but dietary pyridoxine is the main source and no clinically important depletion is established. Notably, both metronidazole and excess pyridoxine can cause peripheral neuropathy.
How serious is the interaction between Metronidazole and Pyridoxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed at usual doses; avoid high-dose pyridoxine during prolonged metronidazole courses and watch for neuropathy symptoms.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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