Drug interactions
Metronidazole + Thiamine
Severity: Minor
Metronidazole and Thiamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral metronidazole could theoretically lower bacterially derived thiamine, but diet is the main source and no clinically meaningful depletion is documented. Thiamine may be given to patients at risk of deficiency regardless.
What this interaction means in plain words
Metronidazole and Thiamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical alteration of intestinal flora that synthesize vitamins.
What to do
No action is needed; continue thiamine supplementation where otherwise indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Metronidazole with Thiamine?
MediHelp rates the interaction as minor. Metronidazole and Thiamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral metronidazole could theoretically lower bacterially derived thiamine, but diet is the main source and no clinically meaningful depletion is documented. Thiamine may be given to patients at risk of deficiency regardless.
How serious is the interaction between Metronidazole and Thiamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed; continue thiamine supplementation where otherwise indicated.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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