Drug interactions
Metronidazole + Zanubrutinib
Severity: Minor
Metronidazole and Zanubrutinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zanubrutinib is mainly cleared by CYP3A4, and moderate or strong inhibitors of this enzyme increase its exposure. Metronidazole is not a recognized moderate CYP3A4 inhibitor, so any increase is probably small. Higher exposure would raise the risk of bleeding, infection and cytopenias.
What this interaction means in plain words
Metronidazole and Zanubrutinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Zanubrutinib belongs to Oncology.
Why it happens
Possible weak inhibition of CYP3A4-mediated zanubrutinib metabolism.
What to do
No routine dose reduction is needed; monitor blood counts and watch for bleeding or infection during a metronidazole course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Metronidazole with Zanubrutinib?
MediHelp rates the interaction as minor. Metronidazole and Zanubrutinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zanubrutinib is mainly cleared by CYP3A4, and moderate or strong inhibitors of this enzyme increase its exposure. Metronidazole is not a recognized moderate CYP3A4 inhibitor, so any increase is probably small. Higher exposure would raise the risk of bleeding, infection and cytopenias.
How serious is the interaction between Metronidazole and Zanubrutinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose reduction is needed; monitor blood counts and watch for bleeding or infection during a metronidazole course.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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