Drug interactions
Miconazole vaginal + Sildenafil
Severity: Minor
Miconazole vaginal and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of vaginal miconazole is low, so a meaningful rise in sildenafil exposure is unlikely at usual doses.
What this interaction means in plain words
Miconazole vaginal and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition by absorbed miconazole.
What to do
No dose adjustment is generally needed. Monitor for sildenafil adverse effects if prolonged or high-dose vaginal therapy is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Frequently asked questions
Can I take Miconazole vaginal with Sildenafil?
MediHelp rates the interaction as minor. Miconazole vaginal and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic absorption of vaginal miconazole is low, so a meaningful rise in sildenafil exposure is unlikely at usual doses.
How serious is the interaction between Miconazole vaginal and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for sildenafil adverse effects if prolonged or high-dose vaginal therapy is used.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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