Drug interactions
Miconazole vaginal + Theophylline
Severity: Minor
Miconazole vaginal and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has limited systemic absorption, though case reports with warfarin show systemic effects can occur. A clinically important rise in theophylline is unlikely.
What this interaction means in plain words
Miconazole vaginal and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Small amounts of absorbed miconazole may inhibit CYP enzymes involved in theophylline metabolism.
What to do
No routine action is required; check theophylline level if toxicity symptoms occur during prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Miconazole vaginal with Theophylline?
MediHelp rates the interaction as minor. Miconazole vaginal and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole has limited systemic absorption, though case reports with warfarin show systemic effects can occur. A clinically important rise in theophylline is unlikely.
How serious is the interaction between Miconazole vaginal and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required; check theophylline level if toxicity symptoms occur during prolonged use.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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