Drug interactions
Midazolam intranasal + Pimozide
Severity: Moderate
Midazolam intranasal and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CNS depressants, so together they can intensify sedation and respiratory depression. Pimozide is a weak CYP3A4 inhibitor, so it may modestly increase midazolam exposure and prolong sedation.
What this interaction means in plain words
Midazolam intranasal and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression, with a minor CYP3A4-mediated rise in midazolam concentrations.
What to do
Monitor respiratory rate, oxygen saturation and level of consciousness after intranasal midazolam. Ensure supervision and resuscitation capability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Midazolam intranasal with Pimozide?
MediHelp rates the interaction as moderate. Midazolam intranasal and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are CNS depressants, so together they can intensify sedation and respiratory depression. Pimozide is a weak CYP3A4 inhibitor, so it may modestly increase midazolam exposure and prolong sedation.
How serious is the interaction between Midazolam intranasal and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, oxygen saturation and level of consciousness after intranasal midazolam. Ensure supervision and resuscitation capability.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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