Drug interactions
Midazolam intranasal + Rabeprazole
Severity: Minor
Midazolam intranasal and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabeprazole has little effect on CYP3A4 and is not expected to alter midazolam exposure to a meaningful degree. Any increase in sedation would be small and theoretical.
What this interaction means in plain words
Midazolam intranasal and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; rabeprazole is at most a very weak CYP3A4 inhibitor.
What to do
No dose adjustment is needed. Observe sedation level as is routine after intranasal midazolam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Midazolam intranasal with Rabeprazole?
MediHelp rates the interaction as minor. Midazolam intranasal and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rabeprazole has little effect on CYP3A4 and is not expected to alter midazolam exposure to a meaningful degree. Any increase in sedation would be small and theoretical.
How serious is the interaction between Midazolam intranasal and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Observe sedation level as is routine after intranasal midazolam.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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