Drug interactions
Mipomersen + Phenytoin
Severity: Moderate
Mipomersen and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise liver enzymes, and mipomersen carries a boxed warning for hepatotoxicity. Using them together may add to liver injury risk and make elevations harder to interpret.
What this interaction means in plain words
Mipomersen and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Monitor liver enzymes and bilirubin at baseline and regularly during combined use. Stop mipomersen if significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Mipomersen with Phenytoin?
MediHelp rates the interaction as moderate. Mipomersen and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise liver enzymes, and mipomersen carries a boxed warning for hepatotoxicity. Using them together may add to liver injury risk and make elevations harder to interpret.
How serious is the interaction between Mipomersen and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin at baseline and regularly during combined use. Stop mipomersen if significant elevations occur.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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