Drug interactions
Mipomersen + Pitavastatin
Severity: Moderate
Mipomersen and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise liver enzymes, so combined use may add to hepatotoxicity. Mipomersen carries a hepatotoxicity warning, and a transporter-mediated effect on pitavastatin is not established.
What this interaction means in plain words
Mipomersen and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The interaction is mainly additive hepatotoxicity; no pharmacokinetic mechanism is established.
What to do
Monitor ALT, AST and bilirubin per the mipomersen REMS schedule. Stop or reduce therapy if enzymes rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
Frequently asked questions
Can I take Mipomersen with Pitavastatin?
MediHelp rates the interaction as moderate. Mipomersen and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise liver enzymes, so combined use may add to hepatotoxicity. Mipomersen carries a hepatotoxicity warning, and a transporter-mediated effect on pitavastatin is not established.
How serious is the interaction between Mipomersen and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin per the mipomersen REMS schedule. Stop or reduce therapy if enzymes rise significantly.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
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