Drug interactions
Mobocertinib + Pimozide
Severity: Major
Mobocertinib and Pimozide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib prolongs the QT interval and also induces CYP3A4, which may reduce pimozide exposure and effect. The combination adds torsades risk while making the pimozide dose unpredictable.
What this interaction means in plain words
Mobocertinib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation combined with CYP3A4 induction by mobocertinib that lowers pimozide levels.
What to do
Avoid coadministration and select an alternative to pimozide. If it cannot be avoided, monitor ECG and electrolytes closely and follow label dose reduction guidance for mobocertinib.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Mobocertinib with Pimozide?
MediHelp rates the interaction as major. Mobocertinib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib prolongs the QT interval and also induces CYP3A4, which may reduce pimozide exposure and effect. The combination adds torsades risk while making the pimozide dose unpredictable.
How serious is the interaction between Mobocertinib and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and select an alternative to pimozide. If it cannot be avoided, monitor ECG and electrolytes closely and follow label dose reduction guidance for mobocertinib.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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