Drug interactions
moclobemide + triptans (e.g., sumatriptan)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Serotonin syndrome risk; avoid.
Mechanism of action
Reversible MAO-A inhibition + 5-HT1B/1D agonist.
Clinical management
Avoid combination.
References
Frequently asked questions
Can I take moclobemide with triptans (e.g., sumatriptan)?
The interaction is rated: Major. Serotonin syndrome risk; avoid.
How serious is the interaction between moclobemide and triptans (e.g., sumatriptan)?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between moclobemide and triptans (e.g., sumatriptan) managed?
Avoid combination.
Why do moclobemide and triptans (e.g., sumatriptan) interact?
Reversible MAO-A inhibition + 5-HT1B/1D agonist.
Full monographs, dosing and an interaction checker in the MediHelp app
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