Drug interactions
Molindone + Venlafaxine
Severity: Moderate
Molindone and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonin-norepinephrine reuptake inhibitor with a dopamine-blocking antipsychotic may increase the risk of serotonin syndrome or neuroleptic malignant syndrome. The risk is low but the outcomes can be serious.
What this interaction means in plain words
Molindone and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects together with dopamine receptor blockade.
What to do
Monitor for agitation, tremor, clonus, hyperthermia and rigidity, particularly at initiation or dose increases. Stop the drugs and treat supportively if either syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Molindone with Venlafaxine?
MediHelp rates the interaction as moderate. Molindone and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonin-norepinephrine reuptake inhibitor with a dopamine-blocking antipsychotic may increase the risk of serotonin syndrome or neuroleptic malignant syndrome. The risk is low but the outcomes can be serious.
How serious is the interaction between Molindone and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, hyperthermia and rigidity, particularly at initiation or dose increases. Stop the drugs and treat supportively if either syndrome is suspected.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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