Drug interactions
Moxisylyte + Perindopril
Severity: Moderate
Moxisylyte and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxisylyte is an alpha-blocking vasodilator and may add to the hypotensive effect of perindopril. An exaggerated drop in blood pressure can occur, particularly after the first dose.
What this interaction means in plain words
Moxisylyte and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through alpha-adrenergic blockade and inhibition of the renin-angiotensin system.
What to do
Start with low doses and monitor blood pressure after the first doses. Advise patients to rise slowly and report dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Moxisylyte and Perindopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Moxisylyte with Perindopril?
MediHelp rates the interaction as moderate. Moxisylyte and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxisylyte is an alpha-blocking vasodilator and may add to the hypotensive effect of perindopril. An exaggerated drop in blood pressure can occur, particularly after the first dose.
How serious is the interaction between Moxisylyte and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor blood pressure after the first doses. Advise patients to rise slowly and report dizziness.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
