Drug interactions
Muromonab cd3 + Tofacitinib
Severity: Major
Muromonab cd3 and Tofacitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Muromonab-CD3 is a potent T-cell depleting immunosuppressant. Combined with tofacitinib it greatly increases the risk of serious and opportunistic infection.
What this interaction means in plain words
Muromonab cd3 and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from T-cell depletion and JAK inhibition.
What to do
Avoid the combination. If tofacitinib must be continued, monitor closely for infection and consider prophylaxis per transplant or immunology protocols.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Muromonab cd3 with Tofacitinib?
MediHelp rates the interaction as major. Muromonab cd3 and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Muromonab-CD3 is a potent T-cell depleting immunosuppressant. Combined with tofacitinib it greatly increases the risk of serious and opportunistic infection.
How serious is the interaction between Muromonab cd3 and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If tofacitinib must be continued, monitor closely for infection and consider prophylaxis per transplant or immunology protocols.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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