Drug interactions
Mycophenolate + Telmisartan-amlodipine
Severity: Moderate
Mycophenolate and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan has been reported to lower mycophenolic acid exposure, possibly by inducing glucuronidation. This could reduce immunosuppressive effect in transplant patients, though evidence is limited.
What this interaction means in plain words
Mycophenolate and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Telmisartan may increase UGT1A9 expression through PPAR-gamma activation, enhancing mycophenolic acid glucuronidation.
What to do
Monitor for signs of graft rejection or reduced immunosuppression, and consider mycophenolic acid level monitoring when telmisartan is started or stopped. Adjust the mycophenolate dose per clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Frequently asked questions
Can I take Mycophenolate with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Mycophenolate and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan has been reported to lower mycophenolic acid exposure, possibly by inducing glucuronidation. This could reduce immunosuppressive effect in transplant patients, though evidence is limited.
How serious is the interaction between Mycophenolate and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of graft rejection or reduced immunosuppression, and consider mycophenolic acid level monitoring when telmisartan is started or stopped. Adjust the mycophenolate dose per clinical response.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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