Drug interactions
Mycophenolate + Telmisartan
Severity: Moderate
Mycophenolate and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan has been reported to lower mycophenolic acid exposure, which could reduce immunosuppressive efficacy in transplant patients. The effect was seen in pharmacokinetic studies and may vary between individuals.
What this interaction means in plain words
Mycophenolate and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Telmisartan upregulates PPAR-gamma, enhancing UGT1A9 expression and increasing glucuronidation and clearance of mycophenolic acid.
What to do
Monitor for signs of reduced immunosuppression and consider mycophenolic acid exposure monitoring in transplant recipients. Adjust the mycophenolate dose accordingly or consider another ARB.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Mycophenolate with Telmisartan?
MediHelp rates the interaction as moderate. Mycophenolate and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan has been reported to lower mycophenolic acid exposure, which could reduce immunosuppressive efficacy in transplant patients. The effect was seen in pharmacokinetic studies and may vary between individuals.
How serious is the interaction between Mycophenolate and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of reduced immunosuppression and consider mycophenolic acid exposure monitoring in transplant recipients. Adjust the mycophenolate dose accordingly or consider another ARB.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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