Drug interactions
Nafcillin + Pimozide
Severity: Minor
Nafcillin and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may lower pimozide exposure, which could reduce its effect. The effect usually fades after nafcillin is stopped.
What this interaction means in plain words
Nafcillin and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nafcillin induces CYP3A4, increasing pimozide clearance.
What to do
Monitor symptom control during nafcillin therapy. Watch for return of higher pimozide exposure and QT effects after nafcillin is discontinued.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Nafcillin with Pimozide?
MediHelp rates the interaction as minor. Nafcillin and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin induces CYP3A4 and may lower pimozide exposure, which could reduce its effect. The effect usually fades after nafcillin is stopped.
How serious is the interaction between Nafcillin and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control during nafcillin therapy. Watch for return of higher pimozide exposure and QT effects after nafcillin is discontinued.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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