Drug interactions
Nafcillin + Rabeprazole
Severity: Minor
Nafcillin and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Rabeprazole depends little on CYP3A4, so a clinically relevant loss of effect is unlikely.
What this interaction means in plain words
Nafcillin and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nafcillin-induced CYP3A4 activity may slightly increase rabeprazole metabolism.
What to do
No adjustment is needed; reassess acid control if symptoms recur during prolonged nafcillin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Nafcillin with Rabeprazole?
MediHelp rates the interaction as minor. Nafcillin and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Rabeprazole depends little on CYP3A4, so a clinically relevant loss of effect is unlikely.
How serious is the interaction between Nafcillin and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; reassess acid control if symptoms recur during prolonged nafcillin therapy.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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