Drug interactions
Nafcillin + Tofacitinib
Severity: Moderate
Nafcillin and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is an inducer of CYP3A4 and may lower tofacitinib concentrations. Reduced efficacy is possible during prolonged courses.
What this interaction means in plain words
Nafcillin and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases tofacitinib clearance.
What to do
Monitor for reduced disease control during nafcillin therapy and reassess once the antibiotic course ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Nafcillin with Tofacitinib?
MediHelp rates the interaction as moderate. Nafcillin and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is an inducer of CYP3A4 and may lower tofacitinib concentrations. Reduced efficacy is possible during prolonged courses.
How serious is the interaction between Nafcillin and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced disease control during nafcillin therapy and reassess once the antibiotic course ends.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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