Drug interactions
Nafcillin + Zolpidem
Severity: Minor
Nafcillin and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower zolpidem concentrations, potentially reducing hypnotic effect. The extent is uncertain.
What this interaction means in plain words
Nafcillin and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4-mediated zolpidem metabolism by nafcillin.
What to do
Monitor sleep response during nafcillin therapy and adjust zolpidem within the labeled range if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zolpidem
Frequently asked questions
Can I take Nafcillin with Zolpidem?
MediHelp rates the interaction as minor. Nafcillin and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin is a CYP3A4 inducer and may lower zolpidem concentrations, potentially reducing hypnotic effect. The extent is uncertain.
How serious is the interaction between Nafcillin and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sleep response during nafcillin therapy and adjust zolpidem within the labeled range if needed.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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