Drug interactions
Nefazodone + Rabeprazole
Severity: Minor
Nefazodone and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor, but rabeprazole is cleared mostly non-enzymatically, so a significant rise in rabeprazole exposure is unlikely. Any increase would likely be of little clinical importance given the wide safety margin of rabeprazole.
What this interaction means in plain words
Nefazodone and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nefazodone inhibits CYP3A4, a minor route of rabeprazole metabolism.
What to do
No dose adjustment is needed. Monitor for PPI adverse effects such as headache or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Nefazodone with Rabeprazole?
MediHelp rates the interaction as minor. Nefazodone and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone is a potent CYP3A4 inhibitor, but rabeprazole is cleared mostly non-enzymatically, so a significant rise in rabeprazole exposure is unlikely. Any increase would likely be of little clinical importance given the wide safety margin of rabeprazole.
How serious is the interaction between Nefazodone and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for PPI adverse effects such as headache or gastrointestinal upset.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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