Drug interactions
Nefazodone + Ulipristal
Severity: Moderate
Nefazodone and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may considerably raise ulipristal levels. The clinical significance is uncertain but increased adverse effects are possible.
What this interaction means in plain words
Nefazodone and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition by nefazodone reduces ulipristal clearance.
What to do
Consider a copper IUD or alternative emergency contraceptive. If ulipristal is used, counsel on possible adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Nefazodone with Ulipristal?
MediHelp rates the interaction as moderate. Nefazodone and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may considerably raise ulipristal levels. The clinical significance is uncertain but increased adverse effects are possible.
How serious is the interaction between Nefazodone and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a copper IUD or alternative emergency contraceptive. If ulipristal is used, counsel on possible adverse effects.
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