Drug interactions
Nefazodone + Zolpidem
Severity: Moderate
Nefazodone and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits CYP3A4 and can raise zolpidem levels, increasing sedation and impairment. Nefazodone is itself sedating, adding to the effect.
What this interaction means in plain words
Nefazodone and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of zolpidem, plus additive sedation.
What to do
Consider a reduced zolpidem dose and monitor for oversedation and next-day impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Frequently asked questions
Can I take Nefazodone with Zolpidem?
MediHelp rates the interaction as moderate. Nefazodone and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone inhibits CYP3A4 and can raise zolpidem levels, increasing sedation and impairment. Nefazodone is itself sedating, adding to the effect.
How serious is the interaction between Nefazodone and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a reduced zolpidem dose and monitor for oversedation and next-day impairment.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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