Drug interactions
Neomycin po + Tenofovir disoproxil
Severity: Moderate
Neomycin po and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin has low absorption, but systemic exposure can rise with bowel inflammation or renal impairment. Together with tenofovir, additive kidney injury and ototoxicity are possible, particularly in patients with existing kidney disease.
What this interaction means in plain words
Neomycin po and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity of aminoglycoside and tenofovir at the proximal tubule.
What to do
Monitor serum creatinine, phosphate and urinary protein during coadministration; avoid prolonged courses in patients with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Neomycin po and Tenofovir disoproxil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Frequently asked questions
Can I take Neomycin po with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Neomycin po and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin has low absorption, but systemic exposure can rise with bowel inflammation or renal impairment. Together with tenofovir, additive kidney injury and ototoxicity are possible, particularly in patients with existing kidney disease.
How serious is the interaction between Neomycin po and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urinary protein during coadministration; avoid prolonged courses in patients with reduced renal function.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
