Drug interactions
Nesiritide + Perindopril
Severity: Moderate
Nesiritide and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nesiritide is a potent vasodilator and combined with perindopril can produce additive hypotension. Symptomatic hypotension and reduced renal perfusion may result, especially in acute heart failure.
What this interaction means in plain words
Nesiritide and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilatory and hypotensive effects.
What to do
Monitor blood pressure and renal function during nesiritide infusion. Reduce or stop the infusion if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Nesiritide with Perindopril?
MediHelp rates the interaction as moderate. Nesiritide and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nesiritide is a potent vasodilator and combined with perindopril can produce additive hypotension. Symptomatic hypotension and reduced renal perfusion may result, especially in acute heart failure.
How serious is the interaction between Nesiritide and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during nesiritide infusion. Reduce or stop the infusion if symptomatic hypotension occurs.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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