Drug interactions
Albuterol + Nilotinib
Severity: Moderate
Albuterol and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib prolongs the QT interval and can cause torsades de pointes. Albuterol can add to this risk, mainly at high doses or with systemic use, through hypokalemia and increased heart rate. The effect is usually modest with inhaled use at standard doses.
What this interaction means in plain words
Albuterol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation, with beta-agonist-induced hypokalemia and tachycardia as contributing factors.
What to do
Check baseline and follow-up ECGs and keep potassium and magnesium within normal range. Prefer the lowest effective albuterol dose and watch for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Albuterol with Nilotinib?
MediHelp rates the interaction as moderate. Albuterol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib prolongs the QT interval and can cause torsades de pointes. Albuterol can add to this risk, mainly at high doses or with systemic use, through hypokalemia and increased heart rate. The effect is usually modest with inhaled use at standard doses.
How serious is the interaction between Albuterol and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and follow-up ECGs and keep potassium and magnesium within normal range. Prefer the lowest effective albuterol dose and watch for palpitations or syncope.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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