Drug reference
nilotinib
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (TK Inhibitors)
Mechanism of action
Selectively binds with high affinity to ATP-binding site of BCR-ABL kinase inhibiting cell proliferation in cell lines and in primary Ph+ CML leukemia cells. Active against imatinib-resistant mutant forms of Bcr-Abl, Inhibits PDGFR and c-Kit kinase.
Common side effects
- Pruritus
- Rash
- Headache
- Fatigue
- Nausea
- Pyrexia
- Diarrhea
Known interactions (6)
- dronedarone + nilotinib Contraindicated
- ergotamine + nilotinib Major
- erythromycin + nilotinib Major
- everolimus + nilotinib Major
- goserelin + nilotinib Major
- indapamide + nilotinib Major
Related conditions
Frequently asked questions
What drug class is nilotinib?
nilotinib belongs to: Oncology.
How does nilotinib work?
Selectively binds with high affinity to ATP-binding site of BCR-ABL kinase inhibiting cell proliferation in cell lines and in primary Ph+ CML leukemia cells. Active against imatinib-resistant mutant forms of Bcr-Abl, Inhibits PDGFR and c-Kit kinase.
What are the common side effects of nilotinib?
Pruritus, Rash, Headache, Fatigue, Nausea, Pyrexia, Diarrhea
Which drugs interact with nilotinib?
dronedarone, ergotamine, erythromycin, everolimus, goserelin, indapamide
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