Drug interactions
Nitrendipine + Phenytoin
Severity: Moderate
Nitrendipine and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP3A4 and can substantially reduce nitrendipine concentrations. This may lead to inadequate blood pressure control.
What this interaction means in plain words
Nitrendipine and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenytoin induction of CYP3A4 increases first-pass and systemic metabolism of nitrendipine.
What to do
Monitor blood pressure and increase the nitrendipine dose if needed, or use an alternative antihypertensive not dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Nitrendipine with Phenytoin?
MediHelp rates the interaction as moderate. Nitrendipine and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces CYP3A4 and can substantially reduce nitrendipine concentrations. This may lead to inadequate blood pressure control.
How serious is the interaction between Nitrendipine and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase the nitrendipine dose if needed, or use an alternative antihypertensive not dependent on CYP3A4.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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