Drug interactions
Nitroglycerin rectal + Olmesartan
Severity: Moderate
Nitroglycerin rectal and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin is a potent vasodilator, and combination with olmesartan can produce additive hypotension, dizziness and syncope. The risk is greater in volume-depleted or elderly patients.
What this interaction means in plain words
Nitroglycerin rectal and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from nitric oxide mediated venous and arterial relaxation and angiotensin II receptor blockade.
What to do
Monitor blood pressure, particularly after the first doses, and counsel patients to rise slowly. Reduce the dose of either agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nitroglycerin rectal and Olmesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Nitroglycerin rectal with Olmesartan?
MediHelp rates the interaction as moderate. Nitroglycerin rectal and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin is a potent vasodilator, and combination with olmesartan can produce additive hypotension, dizziness and syncope. The risk is greater in volume-depleted or elderly patients.
How serious is the interaction between Nitroglycerin rectal and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, particularly after the first doses, and counsel patients to rise slowly. Reduce the dose of either agent if symptomatic hypotension occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
