Drug interactions
Nitroglycerin rectal + Telmisartan-amlodipine
Severity: Moderate
Nitroglycerin rectal and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin is a vasodilator and combined with telmisartan-amlodipine may cause additive blood pressure lowering. Patients may experience dizziness, lightheadedness or fainting.
What this interaction means in plain words
Nitroglycerin rectal and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilatory and hypotensive pharmacodynamic effects.
What to do
Monitor blood pressure and heart rate, particularly when starting nitroglycerin or increasing doses. Counsel patients to rise slowly and reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Frequently asked questions
Can I take Nitroglycerin rectal with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Nitroglycerin rectal and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin is a vasodilator and combined with telmisartan-amlodipine may cause additive blood pressure lowering. Patients may experience dizziness, lightheadedness or fainting.
How serious is the interaction between Nitroglycerin rectal and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly when starting nitroglycerin or increasing doses. Counsel patients to rise slowly and reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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