Drug interactions
Albuterol + Nortriptyline
Severity: Moderate
Albuterol and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may potentiate the cardiovascular effects of beta-agonists, causing tachycardia, palpitations and arrhythmia. At usual inhaled doses the effect is generally modest.
What this interaction means in plain words
Albuterol and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclic blockade of norepinephrine reuptake enhances adrenergic stimulation, with additive effects on heart rate and rhythm.
What to do
Monitor heart rate and blood pressure, especially with high or frequent albuterol doses. Use the lowest effective bronchodilator dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Albuterol with Nortriptyline?
MediHelp rates the interaction as moderate. Albuterol and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may potentiate the cardiovascular effects of beta-agonists, causing tachycardia, palpitations and arrhythmia. At usual inhaled doses the effect is generally modest.
How serious is the interaction between Albuterol and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, especially with high or frequent albuterol doses. Use the lowest effective bronchodilator dose.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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