Drug interactions
Dofetilide + Nortriptyline
Severity: Contraindicated
Dofetilide and Nortriptyline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide is a potent QT-prolonging antiarrhythmic, and nortriptyline can prolong the QT interval too. Combined use increases the risk of torsades de pointes.
What this interaction means in plain words
Dofetilide and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization via potassium channel effects.
What to do
Avoid the combination and choose a non-QT-prolonging antidepressant. Dofetilide is initiated with inpatient ECG monitoring, so review all co-medications before starting.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
- Nortriptyline + Pentamidine Contraindicated
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Nortriptyline?
MediHelp rates the interaction as contraindicated. Dofetilide and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dofetilide is a potent QT-prolonging antiarrhythmic, and nortriptyline can prolong the QT interval too. Combined use increases the risk of torsades de pointes.
How serious is the interaction between Dofetilide and Nortriptyline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antidepressant. Dofetilide is initiated with inpatient ECG monitoring, so review all co-medications before starting.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dronedarone, Ibutilide. The full list is on the Nortriptyline page.
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