Drug interactions
Nystatin + Saccharomyces boulardii
Severity: Moderate
Nystatin and Saccharomyces boulardii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral nystatin acts in the gut lumen and is active against yeasts, so it can kill the live Saccharomyces boulardii. The probiotic would then be unlikely to provide any benefit.
What this interaction means in plain words
Nystatin and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Direct fungicidal activity of nystatin against the probiotic yeast in the gastrointestinal tract.
What to do
Do not give the two together; use a non-yeast probiotic if one is indicated, or start the probiotic after nystatin is finished.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nystatin
Frequently asked questions
Can I take Nystatin with Saccharomyces boulardii?
MediHelp rates the interaction as moderate. Nystatin and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral nystatin acts in the gut lumen and is active against yeasts, so it can kill the live Saccharomyces boulardii. The probiotic would then be unlikely to provide any benefit.
How serious is the interaction between Nystatin and Saccharomyces boulardii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the two together; use a non-yeast probiotic if one is indicated, or start the probiotic after nystatin is finished.
What other medicines interact with Nystatin?
MediHelp also lists interactions of Nystatin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen. The full list is on the Nystatin page.
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